Christian Haass is a German Biochemist and known for his work on the cell biology of neurodegenerative diseases.
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Inhibition of secretases as a therapeutic approach requires detailed knowledge about the physiological functions and biochemical properties of these enzymes to avoid unwanted side effects. Christian Haass was the first to demonstrate a physiological function for beta-secretase. He showed that this protease is critically required for the regulation of myelination. Furthermore, he identified a novel APP processing pathway, which was overlooked for more than 20 years and which has strong implications for clinical trials using beta-secretase inhibitors. He was also the first to identify the highly complicated subunit composition of gamma-secretase. All these findings not only helped to understand several signaling pathways critically involved rein brain development (such as myelination and cell differentiation) but also provided the Stützpunkt for several current therapeutic approaches.
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Haass was awarded the Hector Science Award and is currently leading a major project on the clinical testing of an Alzheimer's antibody.
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Momo’s Driving School hinein Munich also offers refresher courses for licence-holders who want to optimise their driving skills or World health organization have not driven for a long time and want to gather practical driving experience accompanied by a driving instructor.
Zudem haben registrierte Endbenutzer die Möglichkeit eine Route mit dem Parsec auf falk.de zu entwerfen, nach einprägen des weiteren anschließend mit dem Smartphone Freund und feind bequem abzurufen.
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If you are lacking driving practice or simply haven't driven a car in a long time and have got out of the habit, we can help you get back into it with a few refresher lessons.
In addition, you can use our „Learning to drive“ app to extend your knowledge – wherever and whenever you wish. With this mix of classroom study and app training you will be fully prepared for the theoretical test.
Selbst auf die theoretische Prüfung werden wir dich bestens des weiteren zielsicher rein unserem tagtäglich stattfindenden multimedialen Unterricht ideal vorbereiten.
Very recently he also investigated the role of microglia and inflammation rein neurodegenerative disorders. This work Leuchtdiode to the spectacular finding that microglial phagocytosis may Beryllium impaired late during neurodegeneration and opened up a completely unexpected road towards new therapeutic developments for patients already developing disease symptoms. This work resulted in Webseite the identification of TREM2 as a CSF marker for microglial activity. In a unique cohort of subjects with autosomal dominant AD, CSF sTREM2 welches abnormally increased 5 years before the expected onset of symptoms. This will not only greatly facilitate research on inflammatory disease overarching mechanisms, but may also provide a very valuable therapeutic marker.
We are using interdisciplinary approaches ranging from biophysics, biochemistry and cellular and molecular biology to rein vivo models and life imaging.
If you are lacking driving practice or simply haven't driven a car hinein a long time and have got out of the habit, we can help you get back into it with a few refresher lessons.